Flexible layouts prioritize the user experience by allowing designs to adapt to individual preferences and needs. Unlike fixed-width designs, which can lead to wasted space or horizontal scrolling, flexible layouts adjust to the user's browser window size, ensuring that content is always displayed optimally. This adaptability respects user preferences, allowing them to choose how they view the content, which can be particularly beneficial for users with disabilities or those who prefer larger text sizes. By focusing on the user, flexible layouts create a more inclusive and accessible experience for all.